E1231

E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases[1].

Product Specifications

CAS Number

[1031195-19-3]

Product Name Alternative

1-{4-[2- (5-Methylfuran-2-yl) quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/e1231.html

Concentration

10mM

Purity

98.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N1CCN(C(C2=CC(C3=CC=C(C)O3)=NC4=CC=CC=C24)=O)CC1)=O

Molecular Formula

C21H21N3O3

Molecular Weight

363.41

Precautions

H315, H319, H335

References & Citations

[1]Feng T, et al. SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. Atherosclerosis. 2018 Jul;274:172-181.