[Leu144, Arg147]-PLP (139-151)
[Leu144, Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144, Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144, Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE) [1].
Product Specifications
CAS Number
188859-65-6
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/leu144-arg147-plp-139-151.html
Smiles
O=C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC3=CNC=N3)N
Molecular Formula
C67H110N20O17
Molecular Weight
1467.71
References & Citations
[1]Nicholson LB, et al. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc Natl Acad Sci U S A. 1997 Aug 19;94 (17) :9279-84.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC470977-500 1x 500 µL
TGF-beta (1D11.16.8), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880965-100 1x 100 µL
MUC1 / CA15-3 / EMA / CD227 (Epithelial Marker) (VU-11D1), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC681870-100 1x 100 µL
CD10 (Membrane Metalloendopeptidase) (MME/1870), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details