DAP-81
DAP-81 is an inhibitory agent targeting Polo-like kinases (Plks), a class of evolutionarily conserved serine/threonine kinases. DAP-81 dose-dependently increases the number of monopolar spindles in treated cells. High-resolution live-cell microscopy revealed that Plk activity is required for the assembly and maintenance of bipolar mitotic spindles. Plk inhibition destabilizes centromeric microtubules while stabilizing other spindle microtubules, leading to the formation of monopolar spindles. Further testing of compounds based on "privileged scaffolds" such as the DAP scaffold may lead to the discovery of new cell division probes and anti-microtubule agents.
Product Specifications
CAS Number
794466-17-4
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dap-81.html
Smiles
CC(NC1=CC=C(C=C1)NC2=NC=C(C(NC3=CC=CC=C3C(C4=CC=CC=C4)=O)=N2)[N+]([O-])=O)=O
Molecular Formula
C25H20N6O4
Molecular Weight
468.46
References & Citations
[1]Probing cell-division phenotype space and Polo-like kinase function using small molecules
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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