Citrulline-specific probe-rhodamine (hydrate)

Citrulline-specific probe-rhodamine hydrate is a specific probe for citrulline (Citrulline) combined with a rhodamine fluorescent group. Citrulline is the hydrolysis product of arginine catalyzed by protein arginine deiminase (PAD) . PAD is abnormally activated in many diseases, leading to increased citrulline levels. Citrulline-specific probe-rhodamine hydrate is a biological probe that can identify diseases showing abnormal increases in PAD activity and may be effectively used in animal models of ulcerative colitis[1].

Product Specifications

CAS Number

[2309313-01-5]

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/citrulline-specific-probe-rhodamine-hydrate.html

Solubility

10 mM in DMSO

Smiles

O=CC(C1=CC(NC(C(C)N2N=NC(CNC(C3=CC=C4C(C(OC45C6=CC=C(N(C)C)C=C6OC7=CC(N(C)C)=CC=C75)=O)=C3)=O)=C2)=O)=CC=C1)=O.O

Molecular Formula

C39H37N7O8

Molecular Weight

731.75

References & Citations

[1]Bicker K L, Subramanian V, Chumanevich A A, et al. Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination[J]. Journal of the American Chemical Society, 2012, 134 (41) : 17015-17018.