Serotonin-d4

Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

Product Specifications

CAS Number

[58264-95-2]

Product Name Alternative

5-Hydroxytryptamine-d4; 5-HT-d4

UNSPSC

12352005

Hazard Statement

H301, H361

Target

5-HT Receptor; COMT; Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC([2H])([2H])C([2H])([2H])C(C1=C2)=CNC1=CC=C2O

Molecular Formula

C10H8D4N2O

Molecular Weight

180.24

Precautions

H301, H361

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28;8 (8) :e72774.|[3]Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25.