(10E,12Z) -Octadeca-10,12-dienoic acid

(10E,12Z) -Octadeca-10,12-dienoic acid (trans-10, cis-12 CLA2) is an orally active PPARα activator and inhibits adipocyte differentiation. (10E,12Z) -Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z) -Octadeca-10,12-dienoic acid can induce proinflammatory cytokines and chemokines, which would lead to decreased adipogenesis and insulin resistance in adipose tissue. (10E,12Z) -Octadeca-10,12-dienoic acid can affect many aspects of milk fat synthesis. (10E,12Z) -Octadeca-10,12-dienoic acid reduces expression of lipogenic enzymes and inhibits the desaturation of fatty acids. (10E,12Z) -Octadeca-10,12-dienoic acid can reduce lipoprotein lipase (LPL) activity in cultured 3T3-L1 adipocytes and enhance triacylglycerol release from these cells. (10E,12Z) -Octadeca-10,12-dienoic acid decreases the expression of hepatic stearoyl-CoA desatyrase mRNA in mice. (10E,12Z) -Octadeca-10,12-dienoic acid is associated with changes in mucosal NF-κB and Cyclin D1 protein levels in mice[1][2][3][4][5][6].

Product Specifications

CAS Number

[2420-56-6]

Product Name Alternative

Trans-10, cis-12 CLA2

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Lipase; NF-κB; PPAR; Stearoyl-CoA Desaturase (SCD)

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/10e-12z-octadeca-10-12-dienoic-acid.html

Concentration

89.14 mM * 400 μL in Ethanol

Purity

99.10

Solubility

DMSO : ≥ 50 mg/mL

Smiles

CCCCC/C=C\C=C\CCCCCCCCC(O)=O

Molecular Formula

C18H32O2

Molecular Weight

280.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Houseknecht KL, et al. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun. 1998 Mar 27;244 (3) :678-82.|[2]Shultz TD, et al.Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells. Cancer Lett. 1992 Apr 15;63 (2) :125-33. |[3]Park Y, et al Conjugated fatty acids as a prevention tool for obesity and osteoporosis[M]//Emerging trends in dietary components for preventing and combating disease. American Chemical Society, 2012: 393-405|[4]Gervais, R., et al., (2009) . Effects of intravenous infusion of trans-10, cis-12 18:2 on mammary lipid metabolism in lactating dairy cows. Journal of dairy science, 92 (10), 5167–5177. |[5]Park, Y., et al., (1999) . Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids, 34 (3), 235–241.|[6]Rajakangas, J., et al., (2003) . Adenoma growth stimulation by the trans-10, cis-12 isomer of conjugated linoleic acid (CLA) is associated with changes in mucosal NF-kappaB and cyclin D1 protein levels in the Min mouse. The Journal of nutrition, 133 (6), 1943–1948.