ESI-05

ESI-05 is a specific exchange proteins directly activated by cAMP 2 (EPAC2) inhibitor. ESI-05 inhibits cAMP-mediated EPAC2 GEF activity with an IC50 of 0.43 μM. ESI-05 can be used for the research of diabetes, insulin secretion and neurological disorders[1][2].

Product Specifications

CAS Number

[5184-64-5]

Product Name Alternative

NSC 116966

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/esi-05.html

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=C(C)C=C(C)C=C1C)(C2=CC=C(C)C=C2)=O

Molecular Formula

C16H18O2S

Molecular Weight

274.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109 (45) :18613-8.|[2]Yan Zhuang, et al. Inhibition of EPAC2 Attenuates Intracerebral Hemorrhage-Induced Secondary Brain Injury via the p38/BIM/Caspase-3 Pathway. J Mol Neurosci. 2019 Mar;67 (3) :353-363.