WYE-687 (dihydrochloride)
WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1].
Product Specifications
CAS Number
1702364-87-1
UNSPSC
12352005
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wye-687-dihydrochloride.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C(OC)NC1=CC=C(C2=NC(N3CCOCC3)=C4C(N(C5CCN(CC6=CC=CN=C6)CC5)N=C4)=N2)C=C1.[H]Cl.[H]Cl
Molecular Formula
C28H34Cl2N8O3
Molecular Weight
601.53
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; mTORC1; mTORC2; PI3Kα; PI3Kγ
Citation 01
Sci Rep. 2022 Apr 12;12 (1) :6090.|Biosci Rep. 2019 Dec 20;39 (12) :BSR20191041.|Molecules. 2020 Apr 23;25 (8) :1980.
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