MRS1845
MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC50 of 1.7 μM[1]. MRS1845 is an ORAI1 inhibitor[2][3]. MRS1845 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[544478-19-5]
UNSPSC
12352005
Target
Calcium Channel; CRAC Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mrs1845.html
Concentration
10mM
Purity
99.46
Solubility
DMSO : ≥ 125 mg/mL|DMSO : ≥ 83.33 mg/mL|DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)N(CC#C)C(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCC
Molecular Formula
C21H22N2O6
Molecular Weight
398.41
References & Citations
2+2+
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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