L-NIL
L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3].
Product Specifications
CAS Number
53774-63-3
UNSPSC
12352211
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/L-NIL.html
Purity
99.82
Solubility
DMSO : < 1 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
N[C@@H](CCCCNC(C)=N)C(O)=O
Molecular Formula
C8H17N3O2
Molecular Weight
187.24
References & Citations
[1]Moore WM, et al. L-N6- (1-iminoethyl) lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37 (23) :3886-8.|[2]Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635.|[3]Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316 (4) :F624-F634.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
INOS
Available Sizes
Frequently Asked Questions
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