L-NIL

L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3].

Product Specifications

CAS Number

[53774-63-3]

UNSPSC

12352211

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/L-NIL.html

Purity

99.82

Solubility

DMSO : < 1 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

N[C@@H](CCCCNC(C)=N)C(O)=O

Molecular Formula

C8H17N3O2

Molecular Weight

187.24

References & Citations

[1]Moore WM, et al. L-N6- (1-iminoethyl) lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37 (23) :3886-8.|[2]Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635.|[3]Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316 (4) :F624-F634.