Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

ACPT-II

ACPT-II is an antagonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects[1][2][3][4][5].

Product Specifications

CAS Number

195209-04-2

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/acpt-ii.html

Solubility

10 mM in DMSO

Smiles

OC([C@]1(C[C@@H]([C@@H](C1)C(O)=O)C(O)=O)N)=O

Molecular Formula

C8H11NO6

Molecular Weight

217.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Acher FC, et al. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40 (19) :3119-29.|[2]Domin H, et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94.|[3]Domin H, et al. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotox Res. 2014 Jul;26 (1) :99-113.|[4]Chapman AG, et al. Anticonvulsant activity of a mGlu (4alpha) receptor selective agonist, (1S,3R,4S) -1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur J Pharmacol. 2001 Jul 20;424 (2) :107-13.|[5]Stachowicz K, et al. The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems. Neuropharmacology. 2009 Sep;57 (3) :227-34.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Adenine Nucleotide Translocator 2 (SLC25A5) (NM_001152) Human Over-expression Lysate
LY420098 100 µg

Adenine Nucleotide Translocator 2 (SLC25A5) (NM_001152) Human Over-expression Lysate

Sign In for Pricing
View Details
3-Hydroxybutanohydrazide
TRC-B443903-2.5G 2.5 g

3-Hydroxybutanohydrazide

Sign In for Pricing
View Details
Recombinant Reelin Antibody
RC-15602-01 50 μL

Recombinant Reelin Antibody

Sign In for Pricing
View Details
Recombinant Reelin Antibody
RC-15602-02 100 µL

Recombinant Reelin Antibody

Sign In for Pricing
View Details
Recombinant Reelin Antibody
RC-15602-03 1 mL

Recombinant Reelin Antibody

Sign In for Pricing
View Details
NOR1 (NR4A3) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1C1]
TA804891AM 100 µL

NOR1 (NR4A3) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1C1]

Sign In for Pricing
View Details