ACPT-II

ACPT-II is an antagonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects[1][2][3][4][5].

Product Specifications

CAS Number

[195209-04-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/acpt-ii.html

Solubility

10 mM in DMSO

Smiles

OC([C@]1(C[C@@H]([C@@H](C1)C(O)=O)C(O)=O)N)=O

Molecular Formula

C8H11NO6

Molecular Weight

217.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Acher FC, et al. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40 (19) :3119-29.|[2]Domin H, et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94.|[3]Domin H, et al. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotox Res. 2014 Jul;26 (1) :99-113.|[4]Chapman AG, et al. Anticonvulsant activity of a mGlu (4alpha) receptor selective agonist, (1S,3R,4S) -1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur J Pharmacol. 2001 Jul 20;424 (2) :107-13.|[5]Stachowicz K, et al. The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems. Neuropharmacology. 2009 Sep;57 (3) :227-34.