8-Azahypoxanthine
8-Azahypoxanthine is a purine analog and an inhibitor of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) . 8-Azahypoxanthine exhibits antitumor activity and can be used in the research of tumors such as adenocarcinoma[1][2].
Product Specifications
CAS Number
2683-90-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-azahypoxanthine.html
Purity
98.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N=CN1)NN=N2
Molecular Formula
C4H3N5O
Molecular Weight
137.10
Precautions
H302, H315, H319, H335
References & Citations
[1]M H Vaughan, et al. Differential sensitivity of human normal and malignant cells to 8-azahypoxanthine in vitro. Exp Cell Res. 1971, 69, 1.|[2]Bennett LL Jr, et al. Studies with 8-azainosine, a cytotoxic nucleoside with antitumor activity. Cancer Res. 1973 Mar;33 (3) :465-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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