8-Azahypoxanthine

8-Azahypoxanthine is a purine analog and an inhibitor of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) . 8-Azahypoxanthine exhibits antitumor activity and can be used in the research of tumors such as adenocarcinoma[1][2].

Product Specifications

CAS Number

[2683-90-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8-azahypoxanthine.html

Purity

98.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N=CN1)NN=N2

Molecular Formula

C4H3N5O

Molecular Weight

137.10

Precautions

H302, H315, H319, H335

References & Citations

[1]M H Vaughan, et al. Differential sensitivity of human normal and malignant cells to 8-azahypoxanthine in vitro. Exp Cell Res. 1971, 69, 1.|[2]Bennett LL Jr, et al. Studies with 8-azainosine, a cytotoxic nucleoside with antitumor activity. Cancer Res. 1973 Mar;33 (3) :465-71.