PROTAC ER Degrader-4
PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1].
Product Specifications
CAS Number
2361114-15-8
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Estrogen Receptor/ERR; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-er-degrader-4.html
Purity
98.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(F)CN1[C@H](C2=C(C=C(OCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@@H](O)C3)C(N[C@H](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O)C=C2F)F)C6=C(C7=CC=CC=C7N6)C[C@H]1C
Molecular Formula
C53H67F3N6O8S
Molecular Weight
1005.19
Precautions
H315, H319, H320
References & Citations
[1]Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Estrogen receptor; von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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