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PROTAC ER Degrader-4

PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1].

Product Specifications

CAS Number

2361114-15-8

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Estrogen Receptor/ERR; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-er-degrader-4.html

Purity

98.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)(F)CN1[C@H](C2=C(C=C(OCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@@H](O)C3)C(N[C@H](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O)C=C2F)F)C6=C(C7=CC=CC=C7N6)C[C@H]1C

Molecular Formula

C53H67F3N6O8S

Molecular Weight

1005.19

Precautions

H315, H319, H320

References & Citations

[1]Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Estrogen receptor; von Hippel-Lindau (VHL)

Available Sizes

Frequently Asked Questions

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