4-Cyano-3-methylisoquinoline

4-Cyano-3-methylisoquinoline is an inhibitor for protein kinase A (PKA) with an IC50 of micromolar level. 4-Cyano-3-methylisoquinoline reverses morphine tolerance in mouse model[1].

Product Specifications

CAS Number

[161468-32-2]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

PKA

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-cyano-3-methylisoquinoline.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(N=CC2=C1C=CC=C2)C

Molecular Formula

C11H8N2

Molecular Weight

168.19

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Smith FL, et al., The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA. Brain Res. 2003 Sep 19;985 (1) :78-88.