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Ononetin

Ononetin, a natural deoxybenzoin, is a potent and selective TRPM3 channel blocker with an IC50 of 0.3 μM[1].

Product Specifications

CAS Number

[487-49-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TRP Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ononetin.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C(CC(C2=CC=C(O)C=C2O)=O)C=C1

Molecular Formula

C15H14O4

Molecular Weight

258.27

Precautions

H302, H315, H319, H335

References & Citations

[1]I Straub, et al. Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br J Pharmacol. 2013 Apr;168 (8) :1835-50.|[2]Omar Alkhatib, et al. Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits. J Neurosci. 2019 Oct 2;39 (40) :7840-7852.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-108451/Ononetin-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-108451/Ononetin-SDS-MedChemExpress.pdf

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

TRPM3

Available Sizes

Curated Selection

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