Ononetin
Product Specifications
UNSPSC Description
Ononetin, a natural deoxybenzoin, is a potent and selective TRPM3 channel blocker with an IC50 of 0.3 μM[1].
Target Antigen
TRP Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ononetin.html
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(CC(C2=CC=C(O)C=C2O)=O)C=C1
Molecular Weight
258.273
References & Citations
[1]I Straub, et al. Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br J Pharmacol. 2013 Apr;168(8):1835-50.|[2]Omar Alkhatib, et al. Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits. J Neurosci. 2019 Oct 2;39(40):7840-7852.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-108451/Ononetin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-108451/Ononetin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
487-49-0
Available Sizes
Curated Selection
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