Ononetin
Ononetin, a natural deoxybenzoin, is a potent and selective TRPM3 channel blocker with an IC50 of 0.3 μM[1].
Product Specifications
CAS Number
[487-49-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ononetin.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(CC(C2=CC=C(O)C=C2O)=O)C=C1
Molecular Formula
C15H14O4
Molecular Weight
258.27
Precautions
H302, H315, H319, H335
References & Citations
[1]I Straub, et al. Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br J Pharmacol. 2013 Apr;168 (8) :1835-50.|[2]Omar Alkhatib, et al. Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits. J Neurosci. 2019 Oct 2;39 (40) :7840-7852.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
TRPM3
Available Sizes
Curated Selection
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