VISTA-IN-2
VISTA-IN-2 (Compound 1) is an inhibitor of V-domain Ig suppressor of T-cell activation (VISTA) . VISTA-IN-2 induces VISTA degradation in cells through an autophagic mechanism. VISTA-IN-2 rescues VISTA-mediated immunosuppression, and enhances antitumor activity of immune cells. VISTA-IN-2 also activates the antitumor immunity and inhibits tumor growth in a CT26 mouse model[1].
Product Specifications
CAS Number
[2614183-36-5]
UNSPSC
12352005
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vista-in-2.html
Purity
99.44
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=C2NC(C3=CC(CNCCO)=CC=C3)=NC2=CC=C1C4=CC=CC=C4
Molecular Formula
C23H23N3O
Molecular Weight
357.45
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Browse additional items from our catalog
SLC16A14 CRISPRa sgRNA lentivector (set of three targets)(Human)
