VISTA-IN-2
VISTA-IN-2 (Compound 1) is an inhibitor of V-domain Ig suppressor of T-cell activation (VISTA) . VISTA-IN-2 induces VISTA degradation in cells through an autophagic mechanism. VISTA-IN-2 rescues VISTA-mediated immunosuppression, and enhances antitumor activity of immune cells. VISTA-IN-2 also activates the antitumor immunity and inhibits tumor growth in a CT26 mouse model[1].
Product Specifications
CAS Number
[2614183-36-5]
UNSPSC
12352005
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vista-in-2.html
Purity
99.44
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=C2NC(C3=CC(CNCCO)=CC=C3)=NC2=CC=C1C4=CC=CC=C4
Molecular Formula
C23H23N3O
Molecular Weight
357.45
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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HCC-4 (C-C motif chemokine 16 CCL16, Chemokine CC-4, CKb12, HCC-4, IL-10-inducible chemokine (ILINCK), LCC-1, Liver-expressed chemokine (Chemokine LEC), Lymphocyte and monocyte chemoattractant (LMC), Monotactin-1 (MTN-1), New CC chemokine 4 (NCC-4), SCYL4
