Cyclobuxine D

Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum[1][2].

Product Specifications

CAS Number

[2241-90-9]

UNSPSC

12352211

Target

MAChR

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cyclobuxine-d.html

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]([C@H](C)NC)([H])[C@H](O)C2)C)[C@@]5([C@@](C([C@@H](NC)CC5)=C)([H])CC3)C4

Molecular Formula

C25H42N2O

Molecular Weight

386.61

References & Citations

[1]. A. Eshonov, et al. Alkaloids of Buxus sempervirens, Crystal and Molecular Structure of Cyclobuxine-D and Imperialine. Chemistry of Natural Compounds. 12 January 2014. 49:11791182.|[2]Kwon, Jun-Tack, et al. Effects of Cyclobuxine D on Drug-Induced Contractions of the Isolated Rat Uterine Muscle and Potassium-Activated Calcium Channels in an Intestinal Smooth Muscle. The Korean Journal of Pharmacology. 1988. 24 (1) : 103-109.