CCT007093
CCT007093 is an effective protein phosphatase 1D (PPM1D Wip1) inhibitor. Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy[1][2].
Product Specifications
CAS Number
[176957-55-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CCT007093.html
Purity
98.34
Solubility
DMF : 3.33 mg/mL (ultrasonic) |DMSO : ≥ 2.8 mg/mL
Smiles
O=C1/C(CC/C1=C\C2=CC=CS2)=C/C3=CC=CS3
Molecular Formula
C15H12OS2
Molecular Weight
272.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Lingling Zhang, et al. Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin. Hepatology. 2015 Jun;61 (6) :2030-41.|[2]S Rayter, et al. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene. 2008 Feb 14;27 (8) :1036-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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