ATP
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice[1][2][3][4].
Product Specifications
CAS Number
[56-65-5]
Product Name Alternative
Adenosine 5'-triphosphate
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Endogenous Metabolite; Interleukin Related; NOD-like Receptor (NLR)
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ATP.html
Purity
99.88
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=P(O)(O)OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1O)(O)=O)(O)=O
Molecular Formula
C10H16N5O13P3
Molecular Weight
507.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35 (3) :852-8.|[2]M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112 (2) :358-404.|[3]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.|[4]Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8 (5) : e63759.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
IL-1; NLRP3
Citation 01
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