SPC5001
SPC5001 is a locked nucleic acid (LNA) -modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′[1].
Product Specifications
UNSPSC
12352208
Target
PCSK9
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/spc5001.html
Purity
93.97
Solubility
H2O : ≥ 100 mg/mL
Smiles
[SPC5001]
Molecular Weight
4689.85
References & Citations
[1]Nieskens TTG, et, al. Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip. Arch Toxicol. 2021 Jun;95 (6) :2123-2136. |[2]Lindholm MW, Elmén J, Fisker N, et al. PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates. Mol Ther. 2012;20 (2) :376-381.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 1
Frequently Asked Questions
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