Recombinant Human Interleukin-31 (IL31)
Product Specifications
Product Name Alternative
IL-31
Abbreviation
Recombinant Human IL31 protein
Gene Name
IL31
UniProt
Q6EBC2
Expression Region
24-164aa
Organism
Homo sapiens (Human)
Target Sequence
SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
Tag
N-terminal 10xHis-tagged and C-terminal Myc-tagged
Type
In Stock Protein
Source
Baculovirus
Field of Research
Immunology
Relevance
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity (PubMed:15184896) . Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages
Endotoxin
Not test
Purity
Greater than 85% as determined by SDS-PAGE.
Activity
Not Test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Molecular Weight
19.7 kDa
References & Citations
"IL-31: a new link between T cells and pruritus in atopic skin inflammation." Sonkoly E., Muller A., Lauerma A.I., Pivarcsi A., Soto H., Kemeny L., Alenius H., Dieu-Nosjean M.C., Meller S., Rieker J., Steinhoff M., Hoffmann T.K., Ruzicka T., Zlotnik A., Homey B. J. Allergy Clin. Immunol. 117:411-417 (2006)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Product MSDS
https://www.cusabio.com/msds/12927389/
Protein Length
Full Length of Mature Protein
Available Sizes
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