Deslanoside

Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations [1][2][3].

Product Specifications

CAS Number

[17598-65-1]

Product Name Alternative

Deacetyllanatoside C; Desacetyllanatoside C

UNSPSC

12352005

Hazard Statement

H301+H331, H373

Target

Drug Metabolite; Na+/K+ ATPase

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/deslanoside.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O[C@@](O[C@H](C)[C@H]3O[C@@](O[C@H](C)[C@H]4O[C@@](O[C@H](C)[C@H]5O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)([H])C[C@@H]5O)([H])C[C@@H]4O)([H])C[C@@H]3O)C1)C)([H])[C@]2([H])C[C@H]7O)(CC[C@@H]8C(CO9)=CC9=O)[C@]78C

Molecular Formula

C47H74O19

Molecular Weight

943.08

Precautions

H301+H331, H373

References & Citations

[1]Hauptman PJ, et al. Digitalis. Circulation. 1999 Mar 9;99 (9) :1265-70.|[2]Wang L, et al. Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China. Sci Rep. 2017 Oct 23;7 (1) :13819.|[3]Deslanoside.|[4]Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45 (3) :231-8.