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MC 1046

Product Specifications

UNSPSC Description

MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value: Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Target Antigen

VD/VDR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MC-1046.html

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@]1(CCC/2)C(C2=C\C=C3C[C@@H](O)C[C@H](O)C\3=C)CC[C@@H]1[C@H](C)/C=C/C(C4CC4)=O

Molecular Weight

410.59

References & Citations

[1]Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240.|[2]Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829.|[3]Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111|[4]P.J. Marie, D. Connes, M. Hott, L. Miravet. Comparative effects of a novel Vitamin D Analogue MC-903 and 1,25-dihydroxyvitamin D3 on alkaline phosphatase activity, osteocalcin and DNA synthesis by human osteoblastic cells in culture. Bone. Volume 11, Issue 3, 1990, Pages 171-179

Shipping Conditions

Blue Ice

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-15264/MC-1046-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-15264/MC-1046-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

126860-83-1

Available Sizes

Curated Selection

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