Trans-Vaccenic acid

Trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA) . trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation. trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid exerts hypolipidemic effects in a rat model of obesity[1][2][3].

Product Specifications

CAS Number

[693-72-1]

Product Name Alternative

CA-074Me,T-Type calcium channel inhibitor

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; Bcl-2 Family; Endogenous Metabolite

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trans-Vaccenic_acid.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCC/C=C/CCCCCCCCCC(O)=O

Molecular Formula

C18H34O2

Molecular Weight

282.46

Precautions

H315, H319, H335

References & Citations

[1]Li D, et al. Ruminal microbe of biohydrogenation of trans-vaccenic acid to stearic acid in vitro. BMC Res Notes. 2012 Feb 15;5:97.|[2]Song J, et al. Trans-vaccenic acid inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via a mitochondrial-mediated apoptosis pathway. Lipids Health Dis. 2019 Feb 9;18 (1) :46.|[3]Jacome-Sosa MM, et al. Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome. J Nutr Biochem. 2014 Jul;25 (7) :692-701.