BACE1-IN-1
BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
Product Specifications
CAS Number
[1310347-50-2]
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BACE1-IN-1.html
Purity
98.72
Solubility
DMSO : 85 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=C(C#N)C=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)OCC3(F)F)=C2
Molecular Formula
C18H14F3N5O2
Molecular Weight
389.33
References & Citations
[1]Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56 (10) :3980-95.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
BACE1
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal Activin RIIA Antibody (OTI5D1) [Allophycocyanin]](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
NBP2-70079APC 0.1 mL
Mouse Monoclonal Activin RIIA Antibody (OTI5D1) [Allophycocyanin]
Ask
View Details 
132404-HRP 100 µL
RBM9 (RNA Binding Motif Protein 9, RNA Binding Protein 9, Hexaribonucleotide Binding Protein 2, HRNBP2, Repressor of Tamoxifen Transcriptional Activity, RTA) (HRP)
Ask
View Details 