LY-364947
Product Specifications
UNSPSC Description
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, and exhibits 7-fold selectivity over TGFβR-II[1].
Target Antigen
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LY-364947.html
Smiles
C1(C2=CNN=C2C3=NC=CC=C3)=CC=NC4=CC=CC=C14
Molecular Weight
272.30
References & Citations
[1]Peng SB, et al. Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition. Biochemistry, 2005, 44(7), 2293-2304.|[2]Oka M, et al. Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis. Blood, 2008, 111(9), 4571-4579.|[3]Naka K, et al. TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature, 2010, 463(7281), 676-680.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13462/LY-364947-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13462/LY-364947-SDS-MedChemExpress.pdf
CAS Number
396129-53-6
Available Sizes
Curated Selection
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