PRO-6E
PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note: (Blue: Cereblon ligand (HY-103596), Black: linker; Pink: ALK/c-Met inhibitor Crizotinib (HY-50878) ) [1].
Product Specifications
CAS Number
[2353493-69-1]
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pro-6e.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C2=C(OCCCCCCCC(N3CCC(N4C=C(C5=CN=C(N)C(O[C@@H](C6=C(C(F)=CC=C6Cl)Cl)C)=C5)C=N4)CC3)=O)C=CC=C2C(N1C7C(NC(CC7)=O)=O)=O
Molecular Formula
C42H44Cl2FN7O7
Molecular Weight
848.75
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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