CP-601932

CP-601932 ((1S,5R) -CP-601927) is a high-affinity partial agonist at α3β4 nAChR (Ki=21 nM; EC50=~ 3 μM) . CP-601932 has the same high-binding affinity at α4β2 nAChR (Ki=21 nM) and an order of magnitude lower affinity for α6 and α7 nAChR subtypes. CP-601932 selectively decreases ethanol but not sucrose consumption and operant self-administration following long-term exposure. CP-601932 can penetrate the CNS[1].

Product Specifications

CAS Number

[357425-68-4]

Product Name Alternative

(1S,5R) -CP-601927

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cp-601932.html

Purity

99.74

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

FC(F)(C1=CC=C([C@@H]2C[C@H]3CNC2)C3=C1)F

Molecular Formula

C12H12F3N

Molecular Weight

227.23

References & Citations

[1]Chatterjee S, et al. Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats. Neuropsychopharmacology. 2011;36 (3) :603-615.