Schisantherin A

Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.

Product Specifications

CAS Number

[58546-56-8]

Product Name Alternative

Gomisin-C; Schizantherin-A; Wuweizi ester-A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB

Type

Natural Products

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Schisantherin-A.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@]([C@@H](C)C1)(C)[C@@H](OC(C2=CC=CC=C2)=O)C3=CC(OC)=C(OC)C(OC)=C3C4=C1C=C5OCOC5=C4OC

Molecular Formula

C30H32O9

Molecular Weight

536.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Ci X, et al. Schisantherin A exhibits anti-inflammatory properties by down-regulating NF-kappaB and MAPK signaling pathways in lipopolysaccharide-treated RAW 264.7 cells. Inflammation. 2010 Apr;33 (2) :126-36.|[2]Zhou E, et al. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Int Immunopharmacol. 2014 Sep;22 (1) :133-40.