S6K1-IN-1
S6K1-IN-1 is a selective S6K1 inhibitor with an IC50 value of 52 nM. S6K1-IN-1 can be used in the research of obesity and insulin resistance-related diseases[1].
Product Specifications
CAS Number
[1265789-88-5]
UNSPSC
12352005
Target
CDK; JAK; Ribosomal S6 Kinase (RSK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s6k1-in-1.html
Purity
99.71
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NC(NC2=CC3=C(NN=C3)C=C2)=O)SC(C(C)(C)C)=C1)O
Molecular Formula
C17H18N4O3S
Molecular Weight
358.41
References & Citations
[1]Ye P, et al. Potent and selective thiophene urea-templated inhibitors of S6K. Bioorg Med Chem Lett. 2011 Jan 15;21 (2) :849-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK; JAK3; p70S6K
Available Sizes
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