Clavulanic acid

Clavulanic acid is a naturally occurring powerful bacterial β-lactamases inhibitor for research of infections caused by bacteria, including infections of the ears. Clavulanic acid is active against a wide spectrum of gram-positive and gram-negative bacterias[1].

Product Specifications

CAS Number

[58001-44-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/clavulanic-acid.html

Purity

99.76

Solubility

DMSO : 13.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 7 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@H](/C(O[C@]1([H])C2)=C/CO)N1C2=O)O

Molecular Formula

C8H9NO5

Molecular Weight

199.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Parag S Saudagar, et al. Clavulanic acid: a review. Biotechnol Adv. Jul-Aug 2008;26 (4) :335-51|[2]Neu HC, et al. Clavulanic acid, a novel inhibitor of beta-lactamases. Antimicrob Agents Chemother. 1978 Nov;14 (5) :650-5.|[3]Beceiro A, et al. In vitro activity and in vivo efficacy of clavulanic acid against Acinetobacter baumannii. Antimicrob Agents Chemother. 2009 Oct;53 (10) :4298-304.|[4]Soyocak A, et al. Tannic acid exhibits anti-inflammatory effects on formalin-induced paw edema model of inflammation in rats. Hum Exp Toxicol. 2019 Nov;38 (11) :1296-1301.