SIK-IN-1
SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase (SIK), which inhibits SIK1, SIK2 and SIK3 with IC50s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 4 nM in human macrophages[1].
Product Specifications
CAS Number
[3033846-29-3]
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sik-in-1.html
Purity
98.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=C(NC)C=CC2=NC=C(C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3)N21
Molecular Formula
C23H24N6OS
Molecular Weight
432.54
References & Citations
[1]Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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