ST-1006

ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].

Product Specifications

CAS Number

[1196994-11-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/st-1006.html

Purity

99.55

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

ClC(C=CC=C1Cl)=C1CNC2=CC(N3CCN(CC3)C)=NC(N)=N2

Molecular Formula

C16H20Cl2N6

Molecular Weight

367.28

Precautions

H302, H315, H319

References & Citations

[1]Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391 (12) :1387-1397.|[2]Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71 (9) :1264-73.