Zofenopril-d5
Product Specifications
UNSPSC Description
Zofenopril-d5 is deuterium labeled Zofenopril. Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 81 μM.
Target Antigen
Angiotensin-converting Enzyme (ACE); Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease;Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.92
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@H]1N(C([C@H](C)CSC(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)=O)C[C@@H](SC3=CC=CC=C3)C1
Molecular Weight
434.58
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Lin CJ, et al. Competitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles: interaction of ACE inhibitors with high-affinity H+/peptide symporter. Pharm Res. 1999 May;16(5):609-15.|[3]Sarro GD, et al. Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice. Pharmacol Res. 2012 Mar;65(3):285-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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