PVP-037.2
PVP-037.2 is a TLR7/8 agonist. PVP-037.2 can serve as an adjuvant to enhance vaccine-induced TH1 type immune responses, increasing the production of antigen-specific antibodies IgG1 and IgG2c[1].
Product Specifications
CAS Number
3049666-32-9
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pvp-037-2.html
Purity
99.41
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CN2C=C(N=C2N=C1)C3=CC(NC(C4=C(C=C(C=C4)CN)C(F)(F)F)=O)=C(C=C3)C
Molecular Formula
C23H20F3N5O
Molecular Weight
439.43
References & Citations
[1]Soni D, et al. From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation[J]. Science Advances, 2024, 10 (27) : eadg3747.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7; TLR8
Available Sizes
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