BMS-911543
BMS-911543 is a selective JAK2 inhibitor, with IC50s of 1.1 nM, less selective at JAK1, JAK3 and TYK2 (IC50, 75, 360, 66 nM, respectively) .
Product Specifications
CAS Number
1271022-90-2
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BMS-911543.html
Purity
98.23
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(N(C)C=N3)C3=C(NC4=NN(C)C(C)=C4)N=C2N1CC)N(C5CC5)C6CC6
Molecular Formula
C23H28N8O
Molecular Weight
432.52
Precautions
H315, H319, H335
References & Citations
[1]Wan H, et al. Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms. ACS Med Chem Lett. 2015 Jul 12;6 (8) :850-5.|[2]Mace TA, et al. Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer. Oncotarget. 2015 Dec 29;6 (42) :44509-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
JAK1; JAK2; JAK3; Tyk2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7260702-01 48 Well
Porcine CCAAT/Enhancer-Binding Protein gamma ELISA Kit
Sign In for Pricing
View Details MBS7260702-02 96 Well
Porcine CCAAT/Enhancer-Binding Protein gamma ELISA Kit
Sign In for Pricing
View Details MBS7260702-03 5x 96 Well
Porcine CCAAT/Enhancer-Binding Protein gamma ELISA Kit
Sign In for Pricing
View Details MBS7260702-04 10x 96 Well
Porcine CCAAT/Enhancer-Binding Protein gamma ELISA Kit
Sign In for Pricing
View Details 