HDAC6-IN-33

HDAC6-IN-33 (compound 6) is a selective and irreversible HDAC6 inhibitor with an IC50 of 193 nM. HDAC6-IN-33 shows no activity against HDAC1-4. HDAC6-IN-33 is a tight-binding HDAC6 inhibitor capable of inhibiting HDAC6 via a two-step slow-binding mechanism[1].

Product Specifications

CAS Number

[2444302-23-0]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac6-in-33.html

Concentration

10mM

Purity

98.96

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(F)C(O1)=NN=C1C(C=N2)=CN=C2NCC3=CC=CC=C3

Molecular Formula

C14H11F2N5O

Molecular Weight

303.27

References & Citations

[1]Beate König, et al. Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6. J Med Chem. 2023 Oct 12;66 (19) :13821-13837.