BW 755C
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].
Product Specifications
CAS Number
66000-40-6
Product Name Alternative
PPT
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/bw-755c.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NN(C2=CC=CC(C(F)(F)F)=C2)CC1
Molecular Formula
C10H10F3N3
Molecular Weight
229.21
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Hlasta DJ, et al. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J Med Chem. 1991 May;34 (5) :1560-70.|[2]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90 (24) :11693-7.|[3]Tanaka N, et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol. 1991 Feb;260 (2 Pt 1) :E170-4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX; COX-1; COX-2
Available Sizes
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