BW 755C

BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].

Product Specifications

CAS Number

[66000-40-6]

Product Name Alternative

PPT

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

COX; Lipoxygenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/bw-755c.html

Purity

95.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NN(C2=CC=CC(C(F)(F)F)=C2)CC1

Molecular Formula

C10H10F3N3

Molecular Weight

229.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Hlasta DJ, et al. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J Med Chem. 1991 May;34 (5) :1560-70.|[2]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90 (24) :11693-7.|[3]Tanaka N, et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol. 1991 Feb;260 (2 Pt 1) :E170-4.