Prostaglandin A3

Prostaglandin A3 is a non-enzymatic dehydration product of prostaglandin E3 (PGE3) . Prostaglandin A3 showed good affinity for canine EP2 and EP4 receptors with IC50 values of 120 and 20 nM, respectively. The Ki value of Prostaglandin A3 for human PPARγ was 188 μM[1][2][3].

Product Specifications

CAS Number

[36614-31-0]

Product Name Alternative

PGA3

UNSPSC

12352211

Hazard Statement

H225-H319-H336

Target

PPAR; Prostaglandin Receptor

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/prostaglandin-a3.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@@H]([C@H](C=C1)/C=C/[C@H](C/C=C\CC)O)C/C=C\CCCC(O)=O

Molecular Formula

C20H28O4

Molecular Weight

332.43

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Hibbs TA, et al. Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype. Prostaglandins Other Lipid Mediat. 1999 May;57 (2-3) :133-47.|[2]Castleberry TA, et al. Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype. Prostaglandins Other Lipid Mediat. 2001 Jul;65 (4) :167-87.|[3]Ferry G, et al. Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands. Eur J Pharmacol. 2001 Apr 6;417 (1-2) :77-89.