AZ13824374
AZ13824374 is a potent and selective ATAD2 bromodomain inhibitor (pIC50 of 6.9 in HCT116 cells) . AZ13824374 disrupts chromatin interactions and gene transcription by binding to the acetyl-lysine binding site of the ATAD2 bromodomain. AZ13824374 has anticancer activity against breast cancer[1].
Product Specifications
CAS Number
[3040082-19-4]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/az13824374.html
Concentration
10mM
Purity
99.22
Solubility
DMSO : ≥ 200 mg/mL
Smiles
O=C1N[C@H](C(C)C)[C@H]2C3=CC=CC=C3C[C@@H]1N2C(C4=NN5C(C(NC6CCN(CC(C)(F)C)CC6)=C4)=NN=C5C)=O
Molecular Formula
C30H39FN8O2
Molecular Weight
562.68
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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