HIV-IN-11
HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV (IIIb) -infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor[1].
Product Specifications
CAS Number
160729-91-9
UNSPSC
12352005
Target
HIV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hiv-in-11.html
Smiles
O=C([C@@H](C[C@@H](CN1[C@@H](CN(CC1)CC2=CN=C3OC=CC3=C2)C(NC(C)(C)C)=O)O)CC4=CC=CC=C4)N[C@@H]5[C@@H](CC6=C5C=CC=C6)O
Molecular Formula
C38H47N5O5
Molecular Weight
653.81
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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