Naftifine (hydrochloride)

Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition[1].

Product Specifications

CAS Number

[65473-14-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/naftifine-hydrochloride.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic)

Smiles

CN(C/C=C/C1=CC=CC=C1)CC2=CC=CC3=CC=CC=C23.Cl

Molecular Formula

C21H22ClN

Molecular Weight

323.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Georgopoulos, A., et al., In vitro activity of naftifine, a new antifungal agent. Antimicrob Agents Chemother, 1981. 19 (3) : p. 386-9.|[2]Ryder, N.S., G. Seidl, and P.F. Troke, Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans. Antimicrob Agents Chemother, 1984. 25 (4) : p. 483-7.|[3]Parish, L.C., et al., A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris. J Drugs Dermatol, 2011. 10 (10) : p. 1142-7.|[4]Gupta, A.K., J.E. Ryder, and E.A. Cooper, Naftifine: a review. J Cutan Med Surg, 2008. 12 (2) : p. 51-8.