Antalarmin

Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1) antagonist with a Ki of 2.7 nM. Antalarmin can pass through the blood–brain barrier[1][2][3].

Product Specifications

CAS Number

[157284-96-3]

UNSPSC

12352005

Target

CRFR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/antalarmin.html

Purity

99.95

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=C(N2C(C)=C(C)C3=C(N(CCCC)CC)N=C(C)N=C32)C(C)=CC(C)=C1

Molecular Formula

C24H34N4

Molecular Weight

378.55

References & Citations

[1]Ducottet C, et al. Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Jun;27 (4) :625-31.|[2]Dong H, et al. Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice. Psychopharmacology (Berl) . 2014 Dec;231 (24) :4711-22.|[3]Zorrilla EP, et al. Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF) : mediation by CRF1 receptors. Brain Res. 2002 Oct 18;952 (2) :200-10.