Antalarmin
Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1) antagonist with a Ki of 2.7 nM. Antalarmin can pass through the blood–brain barrier[1][2][3].
Product Specifications
CAS Number
157284-96-3
UNSPSC
12352005
Target
CRFR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/antalarmin.html
Purity
99.95
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=C(N2C(C)=C(C)C3=C(N(CCCC)CC)N=C(C)N=C32)C(C)=CC(C)=C1
Molecular Formula
C24H34N4
Molecular Weight
378.55
References & Citations
[1]Ducottet C, et al. Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Jun;27 (4) :625-31.|[2]Dong H, et al. Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice. Psychopharmacology (Berl) . 2014 Dec;231 (24) :4711-22.|[3]Zorrilla EP, et al. Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF) : mediation by CRF1 receptors. Brain Res. 2002 Oct 18;952 (2) :200-10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Ann Med. 2025 Dec;57 (1) :2490823.|Exp Neurol. 2024 May 30:114822.|Immunity. 2024 Feb 13;57 (2) :364-378.e9.|SSRN. 2025 Jun 18.
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