PU.1-IN-1
PU.1-IN-1 is a potent PU.1 inhibitor with an IC50 of 2 nM. PU.1-IN-1 reduces rMANF-induced miR-223 expression. PU.1-IN-1 exhibits anti-inflammatory properties[1][2].
Product Specifications
CAS Number
[873588-27-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MicroRNA
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pu-1-in-1.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(C2CCCCC2)C=C1)(NCC3=CC=NC=C3)=O
Molecular Formula
C18H22N2O2S
Molecular Weight
330.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Li-Huei Tsai, et al. Systems and assays for identifying pu.1 inhibitors. WO2021051016A1.|[2]Xie H, et al. Myeloid-derived MANF ameliorates ethanol-induced liver injury by enhancing microRNA-223 expression. J Gastroenterol. 2025 Jul;60 (7) :877-890.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
K6850-01A-AP 100 µL
KSR (Kinase Suppressor of Ras, KSR1, BKSR1, dKsr, EK31, hb, Positive Ras Signaling Mediator Family Member, RSU2, Suppressor of Activated let 60 Ras SUR3, Suppressor of Ras1 31, SR31) (AP) discontinued
Ask
View Details 
